EPA METHOD 533
US EPA Method 533 employs solid-phase extraction (SPE) liquid chromatography/tandem mass spectrometry (LC/MS/MS) for the precise determination of 25 specific PFAS in drinking water. Enhancing selectivity through Multiple Reaction Monitoring (MRM), the method utilizes isotope dilution for quantification. Addressing some of the more challenging C4 and C5 acids and sulfonates present in EPA methods 537 and 537.1, Method 533 focuses on short-chain PFAS analysis by limiting chain length to C12 acids. Additionally, it introduces certain emerging PFAS using weak anion exchange (WAX) SPE.
EPA METHOD 8327
The dilute-and-shoot liquid chromatography/tandem mass spectrometry (LC/MS/MS) method, known as US EPA Method 8327, enables swift analysis of 24 PFAS in non-potable waters like surface water, groundwater, and wastewater. Aligned with ASTM method D7979 protocols, it employs Multiple Reaction Monitoring (MRM) for improved selectivity, and quantification is achieved through external calibration.
EPA METHOD 1633
The US EPA's provisional Method 1633 is a validated laboratory procedure designed to analyze 40 PFAS compounds spanning nine classes, encompassing linear and branched isomers. This method is applicable to various environmental matrices, such as wastewater, surface water, groundwater, soil, biosolids, sediment, landfill leachate, and fish tissue. It covers not only established PFAS classes but also includes emerging ones, incorporating all analytes found in EPA drinking water Methods 533 and 537.1. This standardized and robust method is crucial for monitoring PFAS in non-potable waters, soils, and tissues to safeguard public health.
